Causative agent
- TGE virus, family Coronaviridae


Differential diagnosis
- Porcine epidemic diarrhea
- Aujeszky's disease
- Porcine rotavirus infection
- Colibacillosis
- Swine dysentery
- Salmonellosis
- Necrotic enteritis


1. Epidemiology
- Seasonal appearance (especially in colder month or
  winter)
- Cats and dogs are possible carriers
- Mechanical carrier such as starling house flies
- Carrier pigs can shed virus for long time


2. Clinical examination
- vomitting, watery yellowish diarrhea, rapid loss of
  weight and dehydration
- High morbidity and mortality in pigs under 2 week
  of age
- Agalactia in lactating sows


3. Necropsy
- Stomach distended with curdled milk, congestion of
  stomach mucosa
- Small intestine distended with yellow and frequent
  foamy fluid and flakes of curdled undigested milk
- Thin and almost transparent intestinal wall

4. Histophathological observation
- Villous atrophy of the jejunum and ileum
- Catarrhal enteritis: vacuolation , degeneration and
  desquamation of epithelial cells and edema in
  lamina propia
- Degeneration of convulated tubule cells in the
  kidney


5. Serological test
Specimens : paried sera
Method      : SN test


6. Antigen dectection
Specimens : small intestine
Method      : FA test on cryostat section


7. Virus isolation
Specimens : small intestine, feces
Method      : CPK, ST, SK-6 cell inoculation and CPE
observation


8. Virus identification
- FA test


Control
- Vaccination
- Sanitary management