Causative agent 
- Isospora suis


Differential diagnosis 
- Strongyloidosis
- Balantidiosis
- Viral, bacterial, parasitic diseases which cause
  diarrhea in neonatal pigs


1. History taking 
- Most common in 5-15 day-old piglets
- Chronic diarrhea in piglets
- Endemic area of coccidiosis
- Acute diarrhea without response to antibiotics



2. Clinical examination 
- Watery or greasy diarrhea, yellowish to white,
  foul smelling
- Anorexia
- Dehydrate
- Vomit
- Dullness and loss weight (undersized)


3. Fecal examination 
- Direct smear
- Flotation technique with saturated sugar solution
- Detection of oocysts

4. Necropsy 
- Slightly thin intestinal wall
- Yellowish and creamy intestinal content
- Diphtheritic membrane on mucosa of intestine



5. Tissue smear 
- Direct scraping of the small intestine for the
  detection of merozoites, schizonts or oocysts



6. Histopathological observation 
- Villous atrophy
- Detection of coccidial parasites in the intestinal
  epithelial cells
- Blunting of villi
- Focal ulceration
- Fibrinonecrotic enteritis

Control and treatment 
- Clean the pen floor with disinfectant vapor or wash
- Treat infected piglets with coccidiocidal drugs
  (Amprolium)
- Feed anticoccidial to sows from 2 weeks before
  farrowing through lactation