Differential diagnosis
- Rabies
- Polioencephalomalacia
- Brain tumor
- Hypovitaminosis A
- Heavy metal poisoning
- Organic pesticides
- infectious encephalitis


Etiology
- Ingestion of paint, plates from storage batteries,
  grease, or used motor oil


1. History taking
- Accidental ingestion of lead in farm
- Young animals are more susceptible than adults


2. Clinical examination
- Acute onset of clinical symptoms and rapid death
Neurological signs:
- Depression
- Ataxia
- Muscle tremor
- Grinding teeth
- Circle
- Push against objects
- Blindness
- Convulsive seizure
Abdominal signs:
- Anorexia
- Excessive salivation
- Transient constipation and diarrhea


3. Necropsy
- Gastritis
- Hyperemia
- Petechial or ecchymotic hemorrhage in various
  organs
- Brain edema

4. Histopathological observation
- Some endothelial swelling and proliferation
- Laminar cortical necrosis
- Cerebellum vascular lesion Purkinje by astro and
  microgliosis


5. Blood analysis
Specimen : whole blood
Method : AAS
- Hematology : presence of nucleated RBC


6. Feed analysis
Specimen : herbage, silage, forage
Method : AAS


7. Tissue analysis
Specimen : kidney (cortex), liver
Method : AAS

Control and treatment
- Intraperitoneal or subcutaneous administration of
  1% to 2% (weight / volume) solution of Ca EDTA in
  5% dextrose, at the rate of 110 mg/kg of body
  weight
- Prevent from having access to lead paint