Causative agent
- FMD virus, family Picornaviridae, seven
serotypes (type O, A, Asia I in Thailand)
Differential diagnosis
- Vesicular stomatitis
- Bovine papular stomatitis
- Vesicular exanthema
- Mucosal disease
- Pox-Herpes-complex
- Swine vesicular disease
1. Epidemiology
- Incubation period 2-8 days
- Highly contagious
- Affect cloven hoofed animals (cattle, buffalo,
sheep, goat, pig)
- High morbidity up to 100%
- Low mortality in adult animals, but often high
in young due to myocarditis
2. Clinical examination
- Fever, depression, anorexia
- Vesicles on mouth, tongue, muzzle, coronary
bands, interdigital space, udder, leading to
salivation and lameness
- Drop in milk production
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3. Antigen detection (typing)
Specimen : vesicular fluid, epithelial tissue from
tongue and feet
Method : ELISA
RT-PCR
4. Virus isolation
Specimen : same as antigen detection
Method : tissue culture (Primary cell culture
more sensitive than cell line)
5. Antibody detection
- LP-ELISA test
- NS-ELISA test
- VN test
Control
- Vaccination
- Control of movement of livestock
- Stamping out
- Zoo sanitation
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